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. Author manuscript; available in PMC: 2015 Dec 10.
Published in final edited form as: Exp Cell Res. 2014 Sep 16;329(2):214–219. doi: 10.1016/j.yexcr.2014.09.001

Figure 1. Cdc42 activity determines polarity and stem cell aging.

Figure 1

Young stem cells are polar for cytoplasmic protein like tubulin (green) and nuclear protein like the acetylated form of histone 4 on lysine 16 (AcH4K16, red). Elevated Cdc42 activity found in aged HSCs turns these cells apolar for both tubulin and AcH4K16, which is tightly connected to aging-associated phenotypes of aged HSCs. Inhibition of Cdc42 activity to the level found in young mice via the specific inhibitor CASIN functionally rejuvenates aged HSCs and reverts apolarity in chronologically aged HSCs into polarity.