Figure 3.

Dihydromyricetin reduces necrosis and inhibits apoptosis of hepatocytes in mice. A: Representative liver section of the control group was stained with hematoxylin and eosin (HE) on day 2 after CCl₄ injection, which shows partial necrosis with clusters of inflammatory cells around the central vein; B: Representative HE stained liver section of DHM administered mice on day 2 after CCl₄ injection, which demonstrates decreased inflammatory cells and histological recovery with only inconspicuous necrosis still remaining around the central vein. In the TUNEL assay earthy yellow cells indicate apoptotic cells; C: The control group; D: Dihydromyricetin (DHM) treated group; E: The numbers of apoptotic cells. At least six 12 mm² tissue sections were counted for each mouse. Values represent mean ± SE (n = 6), ^bP < 0.01 vs control.