Figure 4.

Two-dimensional hierarchical cluster of a gene signature that could discriminate between spontaneous tumors in sham controls and tumors from MS-300 mice. Columns represent samples from different tissues and exposures. Expression values of every gene (rows) are centered by their mean across all tumor samples. The column on the far left denotes the increase (red) or decrease (blue) in fold change in the tumor tissue in response to MS exposure. This heatmap was generated by using the hclust function in the “stats” R package with complete agglomeration and Euclidean distance metrics.