Table 2.
LD50 of fentanyl analogs by different routes in mice.
| LD50 (mg/kg) | |||
|---|---|---|---|
| Comp. | Intravenous | Intraperitoneal | Oral |
| 5 | 57.0 (42.1–77.2) | 113.8 (84.1–153.9) | 285.8 (211.2–386.7) |
| 6 | 45.3 (33.5–61.3) | 107.3 (81.5–141.3) | 220.7 (163.2–298.7) |
| 7 | 35.0 (25.9–47.3) | 277.9 (205.4–376.0) | 717.9 (530.6–971.4) |
| 8 | 44.0 (32.6–59.6) | 349.9 (258.6–473.4) | 903.9 (668.0–1223.0) |
Fentanyl analogs, viz., 5-8 were administered through different routes and acute (24 h) LD50 was determined by Dixon's up and down method (Dixon, 1965). Values in parentheses are fiducial limits at 95% confidence interval.