Fig. 1.

The ideal LD₅₀ values of the drugs in the CAM significantly correlated with LD₅₀ values in mice (A) and rats (B) for intravenous injection. The CAM ideal LD₅₀ was determined based on the average of the LD₅₀ and SD₅₀ after 48 h of exposure to drugs. LD₅₀ values for mice and rats were obtained from the literature and TOXNET. Solid lines indicate regression lines (best-fit lines), and dotted curves indicate 95% confidence bands for the best-fit lines. r²=coefficient of determination. Formulation represent the transformed CAM ideal LD₅₀ to rodents.