Table 1. Formulations for FDA-approved anticancer drugs and the effect of the formulations only on chick embryos.
| Anticancer drugs | Solvents used in formulations# | No. of dead embryos (n=10)# |
|---|---|---|
| Cyclophosphamide | Saline | 0 |
| Cisplatin | Saline | 0 |
| Vincristine | Saline | 0 |
| Mitomycin C | Saline | 1 |
| Aloin | Saline | 0 |
| Camptothecin | 0.025% Sodium hydroxide in saline | 0 |
| Carmustine | 5% Ethanol in saline | 0 |
| Melphalan | 5% cocktail (19:1 of ethanol / 6 N hydrochloric acid) in saline | 1 |
| Actinomycin-D | 1.2% acetone in saline | 1 |
| Paclitaxel | 1.5% cocktail (1:1 of ethanol / Cremophor EL) in saline | 1 |
# Percentage of solvents used in formulations and no. of dead embryos were based on the highest dosages of the drugs administered to the CAM.