Table 2. Toxicity pattern of FDA-approved anticancer drugs in the CAM model 48 hours post administration.

Drugs	Dose (μg/embryo)	Log dose	No. of deaths embryo (n=10)	No. of surviving embryo (n=10)	Cumulative #			% of mortality	% of survival
					Death	Survival	Total
Cyclophosphamide	400	2.6	9	1	18	1	19	94.7	5.3
	125	2.1	7	3	9	4	13	69.2	30.8
	40	1.6	2	8	2	12	14	14.3	85.7
Cisplatin	48	1.68	10	0	18	0	18	100	0
	15	1.18	8	2	8	2	10	80	20
	4.7	0.67	0	10	0	12	12	0	100
Vincristine	0.96	–0.02	10	0	24	0	24	100	0
	0.3	–0.5	10	0	14	0	14	100	0
	0.096	–1	4	6	4	6	10	40	60
Carmustine	120	2.08	9	1	17	1	18	94.4	5.6
	37.5	1.57	5	5	8	6	14	57.1	42.9
	12	1.08	3	7	3	13	16	18.8	81.2
Camptothecin	30	1.48	9	1	18	1	19	94.7	5.3
	9.4	0.97	5	5	9	6	15	60	40
	3	0.48	4	6	4	12	16	25	75
Aloin	200	2.3	7	3	17	3	20	85	15
	62.6	1.8	4	6	10	9	19	52.6	47.4
	19.4	1.29	6	4	6	13	19	31.6	68.4
Mitomycin-C	16.6	1.22	7	3	14	3	17	82.4	17.6
	5.2	0.72	5	5	7	8	15	46.7	53.3
	1.62	0.21	2	8	2	16	18	11.1	88.9
Actinomycin-D	0.006	–2.22	9	1	19	1	20	95	5
	0.002	–2.69	6	4	10	5	15	66.7	33.3
	0.0006	–3.22	4	6	4	11	15	26.7	73.3
Melphalan	31	1.49	8	2	17	2	19	89.5	10.5
	9.7	0.99	7	3	9	5	14	64.3	35.7
	3	0.48	2	8	2	13	15	13.3	86.7
Paclitaxel	9.38	0.97	9	1	17	1	18	94.4	5.6
	3	0.48	4	6	8	7	15	53.3	46.7
	0.92	–0.04	4	6	4	13	17	23.5	76.5

# The formulae for calculating cumulative death / survival were those reported by Reed and Muench [33].