Table 3. Ideal LD50 values (mg/kg) for FDA-approved anticancer drugs in CAM and rodent models.
| Drugs | Model and route of drug administration | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ideal CAM IV | Mice IV | Mice IP | Rats IV | Rats IP | ||||||||||
| mg/kg | log (mg/kg) | mg/kg | log (mg/kg) | mg/kg | log (mg/kg) | mg/kg | log (mg/kg) | mg/kg | log (mg/kg) | |||||
| Cyclophosphamide | 1.79 | –0.32 | 140 | 2.15 | 110 | 2.04 | 148 | 2.17 | 40 | 1.6 | ||||
| Cisplatin | 0.21 | –0.62 | 11 | 1.04 | 6.6 | 0.82 | 8 | 0.9 | 6.4 | 0.81 | ||||
| Vincristine | 0.01 | –2.54 | 3 | 0.48 | 1.3 | 0.11 | 1 | 0 | 1.25 | 0.1 | ||||
| Carmustine | 0.57 | –0.12 | 45 | 1.65 | 21.26 | 1.33 | 13.8 | 1.14 | 17.42 | 1.24 | ||||
| Camptothecin | 0.14 | –0.87 | 38 | 1.58 | 64 | 1.81 | 234 | 2.38 | Not available | Not available | ||||
| Aloin | 0.96 | –0.02 | 200 | 2.3 | 218.00# | 2.34 | >15.00§ | 1.18 | >50.00§ | 1.7 | ||||
| Mitomycin-C | 0.26 | –0.58 | 4 | 0.6 | 4 | 0.6 | 3 | 0.48 | 2 | 0.3 | ||||
| Actinomycin-D | 0.00003 | –4.52 | 1.03 | 0.01 | 0.75 | –0.12 | 0.46 | –0.34 | 0.1 | –1 | ||||
| Melphalan | 0.14 | –0.85 | 20.8 | 1.32 | 10 | 1 | 4.1 | 0.61 | 4.48 | 0.65 | ||||
| Paclitaxel | 0.04 | –1.4 | 12 | 1.08 | 128 | 2.1 | 85 | 1.93 | 32.53 | 1.51 | ||||
Ideal CAM LD50 values were computed from the data in Table 2. The LD50 values for rodents were extracted from the Toxicology Data Network (TOXNET) from United States National Library of Medicine. (http://toxnet.nlm.nih.gov) except for those marked with superscript symbols. # Fahim et al. [12, 13]. § Anderson [4].