Table 2.
Summary of studies investigating mandibular health in rats for 12 weeks or more after ovariectomy.
| Rat strain | Sample size per group | Age at OVX (wks) | OVX duration (wks) | Diet | Technology | Main findings for mandible, compared to sham control | Reference |
|---|---|---|---|---|---|---|---|
| Wistar | n = 5 | 6 | 12 | 1.15% Ca, 0.35% P |
Histomorphometry | (i) 24% decrease in BV | [44] |
|
| |||||||
| Wistar | n = 15 | 35 | 13 | 0.01% Ca | pQCT | (i) 7% decrease in total BMD (ii) 11% decrease in Tb.BMD (iii) 1% decrease in Ct.BMD |
[49] |
|
| |||||||
| Sprague-Dawley | n = 6 | 13 | 16 | Unknown | DXA, pQCT |
(i) No change in BMD (ii) 13% decrease in Tb.BMD (iii) No change in Ct.BMD |
[51] |
|
| |||||||
| Lewis-Brown-Norway | n = 12 | 11 | 16 | Unknown | µ-CT | (i) 18% decrease in BV/TV (ii) 28% decrease in Tb.Th (iii) 67% increase in Tb.Sp (iv) 22% increase in SMI |
[45] |
|
| |||||||
| Wistar | n = 12 | 26 | 16 | 0.1% Ca | pQCT | (i) 3% decrease in total BMD | [50] |
|
| |||||||
| Sprague-Dawley | n = 11 | 28 | 17 | 1.1% Ca, 0.80% P |
DXA, µ-CT |
(i) No change in BMD (ii) 6% decrease in Tb.N (iii) 19% decrease in Conn.D (iv) No change in BV/TV (v) No change in Tb.Th |
[46] |
|
| |||||||
| Sprague-Dawley | n = 15 | 26 | 29 | 1.0% Ca | DXA, histomorphometry | (i) No change in total or molar region BMD (ii) 8% decrease in bone area fraction (iii) No change in area moment of inertia |
[47] |
|
| |||||||
| Lewis-Brown-Norway | n = 6 | 13 | 52 | Unknown | Radiograph | (i) 16% decrease in Ct.Th | [52] |
|
| |||||||
| Fischer | n = 6 | 26 | 52 | 1.15% Ca, 0.88% P, 0.80 IU/g vit. D3 |
µ-CT | (i) 75% decrease in BV/TV (ii) 46% decrease in Tb.Th (iii) 58% decrease in Tb.N (iv) 354% increase in Tb.Sp |
[48] |
BMD, bone mineral density; Tb.BMD, trabecular BMD; Ct.BMD, cortical BMD; BV, bone volume (2D); BV/TV, bone volume (3D); Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness; Ct.Th, cortical thickness; SMI, structure model index; Conn.D, connective density; DXA, dual-energy X-ray absorptiometry; µ-CT, microcomputed tomography.