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. 2015 Mar 10;23(5):907–917. doi: 10.1038/mt.2015.22

Figure 1.

Figure 1

Comprehensive drug delivery system utilizing multifunctional polymer. The first block of the polymer contains three functionalized monomers incorporating ethylene glycol segments to optimize safety and tumor biodistribution, biotin to conjugate targeting αCD22-mAb-SA, and pyridyldisulfide moieties for reversible disulfide conjugation of BIM peptide (1 BIM per polymer). The second block contains DEAEMA and BMA, which provide pH-responsive, endosomal-releasing activity. BMA, butyl methacrylate; DEAEMA, diethylaminoethyl methacrylate.