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. 2015 Mar 10;23(5):907–917. doi: 10.1038/mt.2015.22

Figure 2.

Figure 2

Characterization of αCD22-Pol950-BIM and αCD22-Pol300-BIM conjugates. After formulating polymer–peptide conjugates a HABA assay confirmed streptavidin complexation with (a) Pol950 (squares with blue dashed line) and Pol950-BIM conjugates (circles with solid blue line) and (b) Pol300 (squares with red dashed line) and Pol300-BIM conjugates (circles with solid red line). The number mean diameter of (c) Pol950 (blue solid), Pol950-BIM (blue stripes) and αCD22-Pol950-BIM (blue checkers) and (d) Pol300 (red solid), Pol300-BIM (red stripes), and αCD22-Pol300-BIM (red checkers) micelle particles (n = 3) was measured by DLS at 0.5 mg/ml across a range of five pH values. The hemolytic profile of (e) Pol950 conjugates and (f) Pol300 conjugates (n = 4) at 20 µg/ml across a range of pH values (n = 5) was also evaluated. DLS, dynamic light scattering.