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. 2015 Mar 10;23(5):907–917. doi: 10.1038/mt.2015.22

Figure 4.

Figure 4

Comprehensive metabolic and enzyme panel demonstrates single dose safety profile of αCD22-Pol950-BIM conjugates. A comprehensive metabolic and enzyme panel on major organs was conducted 72 hours after treatment with PBS (black), αCD22-Pol950-BIM (blue), and αCD22-Pol300-BIM (red). The doses administered were 15 mg/kg for αCD22, 300 mg/kg for Pol950, 159 mg/kg for Pol300, and 18 mg/kg for BIM. Data represents the mean ± SD, n = 5; *indicates statistical significance by two-way ANOVA. PBS, sodium phosphate buffer.