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. 2015 Mar 10;23(5):907–917. doi: 10.1038/mt.2015.22

Figure 6.

Figure 6

Intracellular delivery of BIM conjugates extends survival with low dose chemotherapy. Ramos xenograft mice (n = 10) were injected intraperitoneally with cyclophosphamide (35 mg/kg) and bortezomib (0.5 mg/kg) [chemo] 30 minutes before intravenous injection with αCD22 (15 mg/kg), Pol950 (300 mg/kg) or mCTA (115 mg/kg), BIM/LE (18 mg/kg) or BIM (18 mg/kg) on days 6, 9, 12, and 15. A log-rank (Mantel Cox) test was used to determine statistical significance (P < 0.0001) for the Kaplan–Meier survival curve. Mice were euthanized when tumors reached 1250 mm3. The PBS and chemo treatments represent data from three separate studies and chemo+Pol950 from two separate studies. mCTA, macro chain transfer agent.