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. 2015 Mar 17;23(5):875–884. doi: 10.1038/mt.2015.30

Figure 6.

Figure 6

Expression of the TatCARD gene product reduces cellular infiltration observed in the endotoxin-induced uveitis mouse model. (a) Representative histological differences between eyes injected with GFP and eyes injected with sGFP-TatCARD. Eyes were enucleated 24 hours post-lipopolysaccharide injection, fixed, embedded, sectioned, and stained with hematoxylin and eosin. Pictures were taken with a light microscope at original magnifications of 5× and 10×. (b) Expression of the TatCARD gene results in a 64% reduction in the number of infiltrating cells within the vitreous. The number of infiltrating cells was divided by the average number of infiltrating cells per section in the GFP-treated eye (616 cells) and multiplied by 100 to obtain the percentage values. Values represent average ± SD, n = 9 sham-injected eyes, n = 12, GFP- and TatCARD-injected eyes. (c) Expression of the TatCARD gene does not affect the number of infiltrating cells within the anterior chamber. The numbers of infiltrating cells within the anterior chamber were quantified and the absolute numbers standardized to the average number of cells in the GFP-treated eye (206 cells). Values represent average ± SD, n = 10; sham and TatCARD eyes, n = 8 GFP eyes). CARD, caspase activation and recruitment domain.