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. 2015 May 3;34(1):40. doi: 10.1186/s13046-015-0158-1

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© Yang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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FoxM1 is highly expressed in human CRC patients. (A-D): Foxm1 protein expression in CRC cells, normal colon cells and invasive lymph nodes from immunohistochemical staining. The protein expression of FOXM1 was negative (A), mild positive (B), positive (C), strong positive (D), respectively. Scale bar = 100μm. (E): QRT-PCR analyses of colon cancer tissues, invasive lymph nodes and adjacent normal tissues from 4 CRC patients. Foxm1 mRNA expression levels were significantly higher in colon cancer tissues and invasive lymph nodes than paired adjacent normal colon tissues.