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. 2015 May 3;34(1):40. doi: 10.1186/s13046-015-0158-1

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© Yang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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FoxM1-depleted SW620 cells underwent morphological change and effect of FoxM1 on the reversal of EMT in SW620 cells. (A): SW620 cells were transfected with shFOXM1 or control shRNA and incubated for 72hours. Photomicrographs suggested SW620 cells suffered morphologic changes of mesenchymal-to-epithelial transition after knockdown of FOXM1 expression. Scale bar = 50μm. (B): Expression of EMT markers was determined by western blots, β-actin as a loading control. (C-E): Total RNA was extracted from transfected and untransfected SW620 cells by shFOXM1 or control shRNA and subjected to real-time PCR for E-cadherin, Vimentin, and Snail relative mRNA expression. The data were calculated with the 2^-△△C _T Method.