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. 2015 May 6;16(1):54. doi: 10.1186/s12931-015-0214-6

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© Sheridan et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Cox-2 mRNA and protein expression is induced by 2% CSE in Smoker and COPD lung fibroblasts. (A) Cox-2 mRNA- CSE: There was a significant increase in Cox-2 mRNA in COPD lung fibroblasts (black bars) exposed to 2% CSE for 3 hours (*** p <0.05 compared to respective control); there was a significantly more Cox-2 mRNA in COPD fibroblasts at 6 and 24 hours of exposure. There was a trend towards increased Cox-2 mRNA in At Risk fibroblasts (grey bars). Note the lack of relative Cox-2 mRNA induction in Normal lung fibroblasts (white bars). Results are expressed as the mean ± SEM of 4–9 fibroblasts from each subject group. (B) COX-2 protein- CSE: There was a modest induction in COX-2 protein in Normal fibroblasts. There was noticeably more COX-2 protein in the At Risk and COPD fibroblasts. The induction in COX-2 protein occurred earlier COPD fibroblasts (by 3 hours). Representative western blot is shown of at least 3 different experiments.