Table 1. Tissue Distribution Data and Pharmacokinetic Parameters of Gd6L67Ga in Normal Balb/C Mice (n = 4)a.
%ID/g |
|||
---|---|---|---|
Organ | 1 h | 4 h | 24 h |
Blood | 3.51 ± 0.22 | 2.63 ± 0.84 | 0.21 ± 0.06 |
Heart | 1.21 ± 0.13 | 0.94 ± 0.40 | 0.21 ± 0.02 |
Lung | 2.59 ± 0.5 | 1.78 ± 0.87 | 0.38 ± 0.09 |
Liver | 1.39 ± 0.11 | 2.13 ± 0.81 | 1.39 ± 0.24 |
Kidney | 101.32 ± 4.32 | 57.42 ± 17.29 | 43.90 ± 5.12 |
Spleen | 0.73 ± 0.19 | 0.69 ± 0.07 | 0.42 ± 0.12 |
Muscle | 0.27 ± 0.09 | 0.38 ± 0.13 | 0.08 ± 0.02 |
Fat | 0.27 ± 0.10 | 0.27 ± 0.10 | 0.06 ± 0.02 |
Brain | 0.08 ± 0.01 | 0.07 ± 0.02 | 0.02 ± 0.00 |
Two-Compartment Clearance Profile (min) | |||
---|---|---|---|
t1/2α | 11.33 ± 1.31 | t1/2β | 438.37 ± 15.11 |
Data are presented as mean ± standard deviation.