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. 2015 May 12;5:10114. doi: 10.1038/srep10114

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Copyright © 2015, Macmillan Publishers Limited

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Expression of apoptosis-related genes and chromosome euploidy in trophectoderm (TE) cells and arrested primary colonies from cloned blastocysts. (A) All TE cells from cloned blastocysts displayed microdeletion/duplication in certain chromosomes, whereas 80% cells from ICSI blastocysts had normal euploid chromosomes; (B) TE cells from cloned blastocysts showed significant increases in P53 and Bax expression and significant decreases in Bcl-2 expression; ** P < 0.01; (C) All arrested primary colonies from cloned blastocysts showed microdeletion/duplication in certain chromosomes, but the aneuploidy ratio in the arrested primary colonies from ICSI blastocysts was 33.3%; (D) Arrested primary colonies from cloned blastocysts showed significant increases in P53 and Bax expression and significant decreases in Bcl-2 expression; ** P < 0.01.