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. 2015 May 12;5:10114. doi: 10.1038/srep10114

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Copyright © 2015, Macmillan Publishers Limited

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Expression of apoptosis-related genes and chromosome euploidy in arrested primary colonies during virus-mediated iPS induction from different somatic cells. (A) Aneuploidy was observed in significantly higher numbers of arrested colonies from virus-mediated iPS-S2 than in colonies from virus-mediated iPS-S1 or virus-mediated iPS-S3; (B) Increased expression of P53 and Bax and decreased expression of Bcl-2 were observed in arrested colonies from S2 somatic cells, but these differences were less than two-fold; (C) P53 gene expression levels were positively correlated with chromosome aneuploidy in arrested colonies during virus-mediated iPS induction; (D) Significant increases in P53 and Bax and significant decreases in Bcl-2 gene expression were observed in arrested primary colonies with aneuploid chromosomes compared with those with euploid chromosomes; ** P < 0.01.