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. 2015 Mar 25;16(5):628–637. doi: 10.15252/embr.201439846

Figure 2. Hypertension and decreased NO-dependent vasodilation in Cadh5(PAC)-CreERT-Rap1 (Rap1iΔEC) mice.

Figure 2

  • A Representative immunoblot showing complete Rap1 excision in Rap1iΔEC mice, compared with Cre-negative controls. VE-cadherin is included as an EC marker (top blot).
  • B Tail-cuff measurements of systolic blood pressure in Rap1iΔEC and control mice. Values are means ± s.e.m. (n = 3).
  • C, D Decreased NO-dependent vasodilation of preconstricted aortae from Rap1iΔEC mice. Dose-dependent relaxation of control and Rap1iΔEC aortic segments preconstricted with U46619 in response to acetylcholine (ACh) in the absence or presence of L-NAME (C), and in response to sodium nitroprusside (SNP) in the presence of L-NAME (D) (n ≥ 3).

Source data are available online for this figure.