Table 1. Quality of assessment of each included studies.

Trial name or First author	Random sequence generation (selection bias)	Allocation concealment (selection bias)	Blinding of participants and researchers (performance bias)	Blinding of outcome assessment (detection bias)	Incomplete outcome data (attrition bias)	Selective reporting (reporting bias)	Other bias (reports for kinds of adverse effects for intervention )
Bernardinello E, et al./TVVH Study Group.	Low	Unclear	High	High	Low	Low	Low
Valla DC, et al.	Low	Unclear	High	High	Low	Low	Unclear
Nishiguchi S, et al.	Low	Unclear	High	High	Low	Low	Low
Di Bisceglie AM, et al./ HALT-C Trial Investigators	Low	Unclear	High	High	Low	Low	Low
Bruix J, et al./EPIC3 Study Group	Low	Unclear	High	High	Low	Unclear	Low
Kubo S, et al.	Low	Low	High	High	Low	Low	Low
Ikeda K, et al.	Unclear	Unclear	High	High	Low	Low	Low
Mazzaferro V, et al.	Low	Low	High	High	Low	Low	Low
Shiratori Y, et al.	Low	Low	High	High	Low	Low	Low
Miyaguchi S, et al.	Unclear	Unclear	High	High	Low	Low	Low
Ishikawa T, et al	Unclear	Unclear	High	High	Low	Low	High

NOTE. “Low” is “low risk of bias”, that means if bias is present, is unlikely to alter the results.

“Unclear” is “unclear risk of bias”, that means a risk of bias that raises some doubt about the results.

“High risk” is “high risk of bias”, that means bias may alter the results seriously.