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. 2015 May 12;5:10187. doi: 10.1038/srep10187

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The figure shows the electro-thermal model when the applied PEF protocol was 500 V, 70 μs pulse duration, and 200 pulses delivered at 3 Hz. a Finite elements numerical model, and geometry and solved mesh of the rat skin with all major composing layers. The skin is divided into two regions: 1) untreated skin and 2) PEF-treated skin. PEF-treated skin layers are tagged with PEF sign. b 2D map of electric field distribution in the skin slice. c The simulated values of electric field strengths in various skin layers (right panel). d Final simulated temperature distribution immediately after PEF. e. Time-dependent temperature increase in various skin layers during PEF administration.