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. 2015 Apr 30;13:136. doi: 10.1186/s12967-015-0497-x

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© Blattmann et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Establishment of patient-derived mouse model. Human OS tissue was transplanted into 6 mice with success rates of 50% in passage 1 (P1), 66% in passage 2 (P2) and 100% in passage 3 (P3). The number of days until tumor onset decreased from 40 (P1) to 30 (P2) to 20 days (P3).