Table 1.

Pharmacodynamic and pharmacokinetic characteristics of the NOACs

Drugs Characteristics	Dabigatran	Rivaroxaban	Apixaban
Mechanism of action	Direct thrombin (factor IIa) inhibition	Director factor Xa inhibitor	Director factor Xa inhibitor
Oral bioavailability, %	6	> 80	45
Plasma protein blinding, %	35	> 90	87
Time do peak levels, hours	3	2-4	1-3
Half-life, hours	12-17	5-12	9-15
Excretion	80% renal	33% renal, 66% liver	35% renal, 75% fecal