Table 1.

Recovery and survival of mouse platelets transfused into mice of indicated genotype, or transfused into control-liposome or clodronate-liposome treated mice. Recoveries and survival of O-sialoglycoprotein endopeptidase (OSP) treated or untreated mouse platelets transfused into WT mice are also shown. Data are expressed as mean ± s.e.m.

	Survival (h)	Recovery (%)
Platelets transfused into Asgr1−/− mice
22 °C	91.57 ± 2.24**	90.5 ± 3.56
4 °C	71.90 ± 2.12***	75.24 ± 1.63
Platelets transfused into Asgr2−/− mice
22 °C	94.14 ± 1.59***	105.40 ± 2.96
4 °C	72.81 ± 1.29***	75.77 ± 1.04
Platelets transfused into WT mice
22 °C	80.29 ± 2.02	76.83 ± 1.59
4 °C	56.12 ± 2.23	40.57 ± 2.14
Platelets transfused into PBS-liposome treated mice
22 °C	75.03 ± 1.61	74.12 ± 4.25
0 °C	48.33 ± 0.75	64.42 ± 2.60
4 °C, UDP-Glucose	46.354 ± 0.99**	50.92 ± 3.21
4 °C, UDP-Galactose	54.69 ± 3.07	37.08 ± 5.20
Platelets transfused into clodronate-liposome treated mice
22 °C	78.53 ± 2.23	119.0 ± 6.35
0 °C	63.41±3.47*	96.05 ± 1.45
4 °C, UDP-Glucose	49.47 ± 1.91	61.36 ± 5.44
4 °C, UDP-Galactose	55.89 ± 2.76	48.42 ± 2.36
Platelets transfused into control-liposome mice
22 °C, untreated	79.51± 4.497	74.52 ± 10.38
22 °C, OSP-treated	83.58± 5.67	77.15 ± 7.19
4 °C, untreated	56.49± 0.82	45.44 ± 6.44
4 °C, OSP-treated	61.08± 1.75*	67.37 ± 5.01*

^*P < 0.05

^**P < 0.01

^***P < 0.001.