Table 1.
Baseline characteristics by temporal cohort
| 1995–2000 Historical control |
2001–04/2005 Pre-LAS cohort |
5/2005–6/2010 Post-LAS cohort |
p-Value1 | |
|---|---|---|---|---|
| Total transplants | 5081 | 4628 | 7437 | |
| Days of follow-up | 1429 (337, 3306) | 1817 (567, 2593) | 714 (345, 1170) | |
| Demographics | ||||
| Recipient age | 51.0 (40, 58) | 55.0 (44, 60) | 57.0 (47.0, 63) | <0.001 |
| Donor age | 29.0 (19, 42) | 30.0 (20, 44) | 31.0 (21, 46) | <0.001 |
| Gender (male) | 2542 (50.0%) | 2329 (50.3%) | 4337 (58.3%) | <0.001 |
| Time on waitlist (days) | 301 (123, 578) | 298 (106, 680) | 76 (23, 241) | <0.001 |
| Clinical status | ||||
| Medical condition | <0.001 | |||
| ICU | 192 (3.8%) | 163 (3.5%) | 603 (8.2%) | |
| Hospitalized | 300 (6.0%) | 207 (4.5%) | 576 (7.7%) | |
| Not hospitalized | 4543 (90.2%) | 4257 (92.0%) | 6258 (84.1%) | |
| On ventilator | 153 (3.0%) | 122 (2.6%) | 449 (6.0%) | <0.001 |
| On ECMO | 8 (0.2%) | 28 (0.6%) | 79 (1.1%) | <0.001 |
| Candidate diagnosis | <0.001 | |||
| A | 2607 (51%) | 2311 (50%) | 2341 (33%) | |
| B | 290 (6%) | 182 (4%) | 229 (3%) | |
| C | 861 (17%) | 674 (15%) | 935 (13%) | |
| D | 1133 (22%) | 1411 (30%) | 3778 (51%) | |
| Other | 190 (4%) | 50 (1%) | 2 (0.03%) | |
| Ischemic time (min) | 255 (193, 329) | 271 (207, 340) | 398 (236, 363) | <0.001 |
ECMO, extracorporeal membrane oxygenation; ICU, intensive care unit. Diagnosis groups are: A, obstructive lung disease; B, pulmonary vascular disease; C, cystic fibrosis or immunodeficiency disorder and D, restrictive lung disease.
Median and interquartile range for continuous variables; counts and percentages for categorical.
1
Kruskal–Wallis and chi-square tests for continuous and categorical variables, respectively.