Table 9.
Probabilities of carrying mutation in either BRCA1 or BRCA2 (Any BRCA), BRCA1, and BRCA2 for the proband in family 3b for different ethnicity scenarios.
| CARRIER PROBABILITIES FOR THE PROBAND | ||||||
|---|---|---|---|---|---|---|
| ANY BRCA | BRCA1 | BRCA2 | ||||
| Original ethnicity: unspecified/non-AJ (baseline) | 0.0010 | – | 0.0006 | – | 0.0005 | – |
| Mother’s (ID #3) lineage: Italian, Others: unspecified/non-AJ. | 0.0013 | ↑ | 0.0007 | ↑ | 0.0006 | ↑ |
| Mother’s lineage: Italian, Father’s (ID #2) lineage: AJ, Others: unspecified/AJ. | 0.0092 | ↑ | 0.0054 | ↑ | 0.0037 | ↑ |
| Same as above but paternal grandmother (ID #17) non-AJ | 0.0074 | ↑ | 0.0046 | ↑ | 0.0028 | ↑ |
| Same as above but also maternal grandfather (ID #16) non-AJ | 0.0073 | ↑ | 0.0045 | ↑ | 0.0027 | ↑ |