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. 2014 Jul 22;22(10):1829–1838. doi: 10.1038/mt.2014.113

Figure 6.

Figure 6

Quantification of infarct volume after 100 minutes of tMCAO and administration of Anti-miR-103-1, started 20' after ischemia induction coupled with performance of general and focal neurological deficits after Anti-miR drug treatment in ischemic rats. (a) Effect of anti-miR-103-1 9 µg/kg on infarct volume of rats subjected to 100' tMCAO compared to ischemic rats treated with vehicle or with negative control (Neg CTL). The administration of anti-miR-103-1 has been started 20' after tMCAO induction. Rats were sacrified 48 hours after ischemia to ensure the administration of 9 µg (1 µl/hour) of anti-miR. (b) Effect of anti-miR-103-1 9 µg/kg (AntimiRNA 103-1) delayed administered on general and focal scores evaluated when rats were euthanized 48 hours after tMCAO. *P < 0.05 versus 100 minutes of MCAO (vehicle) and versus ischemic rats treated with negative control. n = 5–6 animals per group. Each column represents the mean ± SEM.