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. 2014 Oct 1;22(10):1727–1729. doi: 10.1038/mt.2014.171

Figure 1.

Figure 1

Optimization of TSPO-VDAC1 binding and mitochondrial steroidogenesis via the fusion peptideTVS167. (a) The molecular cooperation among the steroidogenic acute regulatory program (STAR), the voltage-dependent anion channel 1 (VDAC1), and the 18-kDa translocator protein (TSPO) is core to the transduceosome complex and drives steroidogenesis. (b) During hormone stimulation, the mitochondrial recruitment of 14-3-3ε prevents the functional interaction between VDAC1 and TSPO, thereby perturbing steroidogenesis. (c) TAT-VDAC1 Ser167 (TVS167) prevents the interaction between 14-3-3ε and VDAC1, facilitating TSPO-VDAC1 binding and steroidogenesis. ANT, adenine nucleotide translocase; IMM, inner mitochondrial membrane; OMM, outer mitochondrial membrane.