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. 2015 May 12;2:18. doi: 10.3389/fmolb.2015.00018

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Copyright © 2015 Pudasaini, El-Arab and Zoltowski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LOV optogenetic tools. Existing LOV-based tools exploit one of two possible mechanisms. (A) LOV and effector are attached through a helical linker to create an inhibitory surface that is released following photoexcitation. (B) An effector molecule is split into two inactive components. Light activation induces LOV-mediated dimer formation to activate the effector molecule.