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. 2015 May 12;2:18. doi: 10.3389/fmolb.2015.00018

Figure 4.

Figure 4

LOV signaling mechanisms. (A) Dark (gray) and light (cyan) state structures of AsLOV2. Photoactivation leads to rotation of Q101 to alter H-bonding contacts to N2. N2 undergoes a light driven interchange involving contacts with D103 and Q101. The H-bond switch affects Ncap structure to disorder the Jα helix. (B) Dark (gray) and light (cyan) state structures of VVD. C4a adduct formation promotes rotation of Q101 to alter H-bonds to A2. Movement of the Ncap reorientates C1 to disrupt contacts with D-2, leading to rearrangement of the Ncap and dimer formation. (C) (YtvA) and (D) (EL222) mechanisms are less understood but likely involve Q101 and H-bonding contacts (black dotted line) to neighboring residues.