Fig. (2).

Chronic model of a combination of hypertension and large blood pressure variability. A. 24-h records of mean blood pressure (mBP) under the unrestricted, conscious condition. B. Representative microphotographs of Mallory-Azan-stained left ventricles. C. Pooled data of changes in myocyte diameter (a), %myocardial fibrosis area (b), and left ventricular (LV) fractional shortening (c). WKY, Wistar Kyoto rat; SHR, spontaneously hypertensive rat; SAD, bilateral sino-aortic denervation. Modified from Kudo et al [20].