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Effects of non-depressor dose of eplerenone (EPL) on the large blood pressure variability-induced hypertensive cardiac remodeling in SHR. A. Pooled data showing the changes in myocyte diameter and %myocardial fibrosis. B. Pooled data showing the changes in braintype natriuretic peptide (BNP) mRNA expression (a) and transforming growth factor-β (TGF-β) mRNA expression (b), and macrophage infiltration (c). SAD, bilateral sino-aortic denervation. Modified from Yasuoka et al [33].
