Table 7.
Allele and haplotype association analysis for sigmoid colon cancer
| M1 a | M2 b | M3 c | Case | Control | Case-Freq | Control-Freq | OR (95% C.I.) | Chisq | P value |
|---|---|---|---|---|---|---|---|---|---|
| C | - | - | 33.0 | 111.0 | 0.79 | 0.56 | ref. d | ||
| T | - | - | 9.0 | 89.0 | 0.21 | 0.45 | 0.34 (0.15–0.75) | 7.668 | 0.0056 |
| - | G | - | 32.0 | 108.0 | 0.73 | 0.54 | ref. | ||
| - | T | - | 12.0 | 92.0 | 0.27 | 0.46 | 0.44 (0.21–0.90) | 5.172 | 0.023 |
| - | - | C | 23.0 | 100.0 | 0.52 | 0.50 | ref. | ||
| - | - | T | 21.0 | 100.0 | 0.48 | 0.50 | 0.91 (0.48–0.76) | 0.075 | 0.78 |
| C | G | - | 30.0 | 97.4 | 0.71 | 0.49 | ref. | 7.104 | 0.0077 |
| C | T | - | 3.0 | 13.6 | 0.07 | 0.07 | 0.72 (0.19–2.68) | 0.018 | 0.89 |
| T | G | - | 0.0 | 10.6 | 0.00 | 0.05 | not calculable | 2.237 | 0.13 |
| T | T | - | 9.0 | 78.4 | 0.21 | 0.39 | 0.37 (0.16–0.83) | 4.916 | 0.027 |
| C | - | C | 22.0 | 91.0 | 0.52 | 0.48 | ref. | 0.277 | 0.60 |
| C | - | T | 11.0 | 16.0 | 0.26 | 0.08 | 2.84 (1.16–6.98) | 10.560 | 0.0012 |
| T | - | T | 9.0 | 83.0 | 0.21 | 0.44 | 0.45 (0.20–1.03) | 7.120 | 0.0076 |
| - | G | C | 21.9 | 90.3 | 0.50 | 0.45 | ref. | 0.328 | 0.57 |
| - | G | T | 10.1 | 17.7 | 0.23 | 0.09 | 2.37 (0.94–5.92) | 7.129 | 0.0076 |
| - | T | C | 1.1 | 9.7 | 0.03 | 0.05 | 0.49 (0.06–4.09) | 0.539 | 0.46 |
| - | T | T | 10.9 | 82.3 | 0.25 | 0.41 | 0.55 (0.25–1.20) | 4.085 | 0.043 |
| C | G | C | 21.0 | 83.2 | 0.50 | 0.44 | ref. | 0.540 | 0.46 |
| C | G | T | 9.0 | 10.3 | 0.21 | 0.05 | 3.48 (1.23–9.82) | 11.390 | 0.00074 |
| C | T | C | 1.0 | 7.8 | 0.02 | 0.04 | 0.51 (0.06–4.37) | 0.289 | 0.59 |
| C | T | T | 2.0 | 5.7 | 0.05 | 0.03 | 1.38 (0.25–7.65) | 0.488 | 0.49 |
| T | G | T | 0.0 | 7.6 | 0.00 | 0.04 | not calculable | 1.596 | 0.21 |
| T | T | T | 9.0 | 75.5 | 0.21 | 0.40 | 0.47 (0.20–1.10) | 5.173 | 0.023 |
aM1 1236 C > T rs1128503.
bM2 2677 G > T/A rs2032582.
cM3 3435 C > T rs1045642.
dreference.