Table 8.
CRC male (case) versus CRC female (control) allele and haplotype association analysis
| M1 a | M2 b | M3 c | Male | Female | Male-Freq | Fem-Freq | OR (95% C.I.) | Chisq | P value |
|---|---|---|---|---|---|---|---|---|---|
| C | - | - | 71 | 41 | 0.68 | 0.47 | ref. d | - | - |
| T | - | - | 33 | 47 | 0.32 | 0.53 | 0.40 (0.23–0.73) | 9.22 | 0.0024 |
| - | G | - | 66 | 43 | 0.63 | 0.47 | ref. | - | - |
| - | T | - | 38 | 49 | 0.37 | 0.53 | 0.50 (0.29–0.90) | 5.53 | 0.019 |
| - | - | C | 60 | 41 | 0.59 | 0.45 | ref. | - | - |
| - | - | T | 42 | 51 | 0.41 | 0.55 | 0.56 (0.32–0.99) | 3.94 | 0.047 |
| C | G | - | 63.8 | 34.7 | 0.61 | 0.39 | ref. | 9.09 | 0.003 |
| C | T | - | 7.2 | 6.3 | 0.07 | 0.07 | 0.61 (0.19–1.99) | 0.00 | 0.99 |
| T | G | - | 2.2 | 5.3 | 0.02 | 0.06 | 0.22 (0.04–1.21) | 1.88 | 0.17 |
| T | T | - | 30.8 | 41.7 | 0.30 | 0.47 | 0.4 (0.22–0.75) | 6.61 | 0.010 |
| C | - | C | 52.5 | 27.9 | 0.52 | 0.32 | ref. | 7.68 | 0.0056 |
| C | - | T | 17.5 | 13.2 | 0.17 | 0.15 | 0.70 (0.28–1.75) | 0.26 | 0.61 |
| T | - | C | 7.5 | 11.2 | 0.07 | 0.13 | 0.35 (0.11–1.13) | 1.49 | 0.22 |
| T | - | T | 24.5 | 35.9 | 0.24 | 0.41 | 0.36 (0.18–0.72) | 6.78 | 0.009 |
| - | G | C | 51.8 | 33.4 | 0.51 | 0.36 | ref. | 4.41 | 0.036 |
| - | G | T | 13.2 | 9.6 | 0.13 | 0.10 | 0.89 (0.33–2.39) | 0.26 | 0.61 |
| - | T | C | 8.2 | 7.6 | 0.08 | 0.08 | 0.70 (0.22–2.23) | 0.02 | 0.90 |
| - | T | T | 28.8 | 41.4 | 0.28 | 0.45 | 0.45 (0.24–0.86) | 5.90 | 0.015 |
| C | G | C | 49.0 | 27.4 | 0.50 | 0.32 | ref. | 6.35 | 0.012 |
| C | G | T | 12.9 | 7.4 | 0.13 | 0.09 | 0.97 (0.34–2.81) | 0.99 | 0.32 |
| C | T | T | 4.1 | 6.2 | 0.04 | 0.07 | 0.37 (0.10–1.45) | 0.71 | 0.40 |
| T | G | C | 2.1 | 3.2 | 0.02 | 0.04 | 0.37 (0.06–2.39) | 0.33 | 0.57 |
| T | T | C | 5.9 | 7.4 | 0.06 | 0.09 | 0.44 (0.13–1.58) | 0.55 | 0.46 |
| T | T | T | 24.0 | 34.4 | 0.24 | 0.40 | 0.39 (0.19–0.79) | 5.33 | 0.021 |
aM1 1236 C > T rs1128503.
bM2 2677 G > T/A rs2032582.
cM3 3435 C > T rs1045642.
dreference.