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. Author manuscript; available in PMC: 2015 May 12.
Published in final edited form as: Biol Psychiatry. 2013 Aug 1;75(5):398–405. doi: 10.1016/j.biopsych.2013.06.016

Figure 3.

Figure 3

Exploratory Whole Brain Analysis.


Cluster Index Z x y z FSL Harvard-Oxford Cortical Atlas Label

Blue 3.8 -22 -68 8 Left Intracalcarine Cortex
Blue 3.84 -18 -48 -2 Left Lingual Gyrus
Blue 3.98 20 72 10 Left Intracalcarine Cortex
Blue 4.25 -12 -40 -4 Left Parahippocampal Gyrus, posterior division; extending into the Left Lingual Gyrus
Green 3.45 -46 -14 18 Left Central Opercular Cortex
Green 3.46 -50 -24 2 Left Planum Temporale
Green 3.72 -48 -22 6 Left Heschl's Gyrus
Green 4.11 -6 -22 28 Left Cingulate Gyrus, posterior division

Peak DLPFC Voxel 2.67 -36 30 24 Left Middle Frontal Gyrus (p<0.004, uncorrected)

Exploratory whole brain comparison of rs1625579 TT versus GG/TG genotypes showed two significant clusters (z=2.3, p<0.05), which included peak activations in the Left Cingulate Gyrus - posterior division, Left Heschl's Gyrus extending into the Left Planum Temporale, the left Central Opercular Cortex, the Left Parahippocampal Gyrus – posterior division, extending in the Left Lingual Gyrus and Left Intracalcarine Cortex; Left Figure). Exploratory examination beyond the significant clusters, for the rs1625579 TT > rs1625579 GG/TG genotype contrast at z=2.67, p<0.004 (uncorrected) showed significant voxels in the Left Middle Frontal Gyrus activation (Right Figure).