Appendix 1.
GENES AND MUTATIONS INVESTIGATED
| AKT1_E17K_G49A | FGFR1_S125L_C374T | MET_Y1248C_A3743G |
| AKT2_E17K_G49A | FGFR2_N549KK_T1647GA | MET_Y1248HD_T3742CG |
| AKT3_E17K_G49A | FGFR2_S252W_C755G | MET_Y1253D_T3757G |
| ALK_F1174CS_T3521GC | FGFR3_G370C_G1108T | MGA_T1747N_C5421A |
| ALK_F1174L_C3522AG | FGFR3_G380R_G1138A | NRAS_A146T_G436A |
| ALK_F1174LIV_T3520CAG | FGFR3_G697C_G2089T | NRAS_G12DAV_G35ACT |
| ALK_F1245C_T3734G | FGFR3_K650MT_A1949TC | NRAS_G12SRC_G34ACT |
| ALK_F1245L_C3735AG | FGFR3_R248C_C742T | NRAS_G13DAV_G38ACT |
| ALK_F1245VI_T3733GA | FGFR3_S249C_C746G | NRAS_G13SRC_G37ACT |
| ALK_I1171N_T3512A | FGFR3_Y373C_A1118G | NRAS_Q61EKX_C181GAT |
| ALK_R1275QL_G3824AT | FOXL2_C134W_C402G | NRAS_Q61HHQ_A183TCG |
| BCOR_N1407STI_A4220GCT | GNA11_Q209LP_A626TC | NRAS_Q61RPL_A182GCT |
| BRAF_D594GV_A1781GT | GNA11_R183C_C547T | PDGFRA_D842V_A2525T |
| BRAF_E586K_G1756A | GNAQ_Q209H_A627T | PDGFRA_D842YN_G2524TA |
| BRAF_G464EVA_G1391ATC | GNAQ_Q209LPR_A626TCG | PDGFRA_N659K_C1977A |
| BRAF_G466EVA_G1397ATC | GNAS_R201H_G602A | PDGFRA_N659Y_A1975T |
| BRAF_G466R_G1396CA | GNAS_R201SC_C601AT | PDGFRA_V561D_T1682A |
| BRAF_G469EVA_G1406ATC | GRM3_E870K_G2608A | PIK3CA_A1046V_C3137T |
| BRAF_G469R_G1405CA | IDH1_G70D_G209A | PIK3CA_C420R_T1258C |
| BRAF_K601E_A1801G | IDH1_R132CGS_C394TGA | PIK3CA_E110K_G328A |
| BRAF_L597RQ_T1790GA | IDH1_R132HL_G395AT | PIK3CA_E418K_G1252A |
| BRAF_V600_G1800 | IDH1_V178I_G532A | PIK3CA_E453K_G1357A |
| BRAF_V600EAG_T1799ACG_F | IDH2_R140LQ_G419TA | PIK3CA_E542KQ_G1624AC |
| BRAF_V600EAG_T1799ACG_R | IDH2_R140W_C418T | PIK3CA_E542VG_A1625TG |
| BRAF_V600LM_G1798TA | IDH2_R172GW_A514GT | PIK3CA_E545AGV_A1634CGT |
| CC2D1A_L913V_C3036G | IDH2_R172MK_G515TA | PIK3CA_E545D_G1635CT |
| CDK4_R24C_C70T | IDH2_R172S_G516T | PIK3CA_E545KQ_G1633AC |
| CDK4_R24H_G71A | JAK2_V617F_G1849T | PIK3CA_F909L_C2727G |
| CSMD1_A409S_G1225T | KIT_D816GVA_A2447GTC | PIK3CA_G118D_G353A |
| CSMD1_Q3005X_C9013T | KIT_D816HNY_G2446CAT | PIK3CA_H1047RL_A3140GT_F |
| CTNNB1_D32AGV_A95CGT | KIT_K642E_A1924G | PIK3CA_H1047RL_A3140GT_R |
| CTNNB1_D32HNY_G94CAT | KIT_L576P_T1727C | PIK3CA_H1047Y_C3139T |
| CTNNB1_G34EVA_G101ATC | KIT_N566D_A1696G | PIK3CA_H701P_A2102C |
| CTNNB1_H36PRY_A107CGT | KIT_N822KNK_T2466GCA | PIK3CA_K111N_G333C |
| CTNNB1_I35NST_T104AGC | KIT_N822YHD_A2464TCG | PIK3CA_M1043I_G3129ATC |
| CTNNB1_S33APT_T97GCA | KIT_R634W_C1900T | PIK3CA_M1043V_A3127G |
| CTNNB1_S37CFY_C110GTA | KIT_V559ADG_T1676CAG | PIK3CA_N345K_T1035A |
| CTNNB1_S45APT_T133GCA | KIT_V560DGA_T1679AGC | PIK3CA_P539R_C1616G |
| CTNNB1_S45CFY_C134GTA | KIT_V825A_T2474C | PIK3CA_Q060K_C178A |
| CTNNB1_T41APS_A121GCT | KIT_Y553N_T1657A | PIK3CA_Q546EK_C1636GA |
| CTNNB1_T41INS_C122TAG | KRAS_A146PT_G436CA | PIK3CA_Q546LPR_A1637TCG |
| EGFR_G719CS_G2155TA | KRAS_G10R_G28A | PIK3CA_R088Q_G263A |
| EGFR_K860I_A2579T | KRAS_G12DAV_G35ACT | PIK3CA_S405F_C1214T |
| EGFR_L858R_T2573G | KRAS_G12SRC_G34ACT | PIK3CA_T1025SA_A3073TG |
| EGFR_L861QR_T2582AG | KRAS_G13DAV_G38ACT | PIK3CA_Y1021C_A3062G |
| EGFR_S720P_T2158C | KRAS_G13SRC_G37ACT | PIK3CA_Y1021HN_T3061CA |
| EGFR_T790M_C2369T | KRAS_Q61EKX_C181GAT | PPP2R1A_W257G_T769G |
| EGFR_T854I_C2561T | KRAS_Q61HHQ_A183CTG | RAF1_A319S_G955T |
| EGFR_Y813C_A2438G | KRAS_Q61LPR_A182TCG | RAF1_L613V_C1837G |
| EPHA3_K761NN_G2283TC | MAP2K2_E207KQ_G619AC | RAF1_N115S_A344G |
| FBXO4_L23Q_T68A | MAP2K7_D290D_C870T | RAF1_Q335H_G1005C |
| FBXO4_P76T_C226A | MAP2K7_R162H_G485A | RAF1_S259A_T775G |
| FBXO4_S8R_C24AG | MAP2K7_S271T_T811A | RAF1_Y340D_T1018G |
| FBXW7_R465C_C1393T | MAP2K7_S311L_C932T | RET_M918T_T2753C |
| FBXW7_R465HL_G1394AT | MET_H1112RL_A3335GT | RPL22_K15TRM_A44CGT |
| FBXW7_R479QL_G1436AT | MET_H1112Y_C3334T | SFRS9_Y192X_C722A |
| FBXW7_R505CS_C1513TA | MET_M1268T_T3803C | SMO_A324T_G970A |
| FBXW7_R505HLP_G1514ATC | MET_N375S_A1124G | SRC_Q531X_C1591T |
| FBXW7_S582L_C1745T | MET_R988C_C2962T | TGM2_S212P_T734C |
| FGFR1_P252T_C754A | MET_T1010I_C3029T |