TABLE 1.
Clinical and biochemical features of sisters and control women
| Variable | PCOS (n = 51) | HA (n = 38) | UA (n = 143) | Controls (n = 125) | P |
|---|---|---|---|---|---|
| Age (yr) | 28 ± 7a | 26 ± 6a | 31 ± 9 | 33 ± 8 | <0.001 |
| BMI (kg/m2) | 32.9 ± 7.0b | 29.4 ± 5.9c | 26.6 ± 6.4d | 30.8 ± 8.2 | <0.001 |
| Waist (cm) | 96 ± 16 | 87 ± 15 | 82 ± 13 | 91 ± 16 | 0.13 |
| Systolic (mm Hg) | 119 ± 15 | 118 ± 12 | 114 ± 14 | 115 ± 11 | 0.06 |
| Diastolic (mm Hg) | 72 ± 10 | 71 ± 7 | 70 ± 9 | 73 ± 10 | 0.67 |
| T (ng/dl) | 82 ± 37a | 74 ± 20a | 30 ± 12 | 28 ± 10 | <0.001 |
| uT (ng/dl) | 26 ± 14a | 23 ± 11a | 6 ± 3 | 6 ± 3 | <0.001 |
| Glucose (mg/dl) | 89 ± 10e | 84 ± 8 | 87 ± 8e | 84 ± 8 | <0.001 |
| Insulin (µU/ml) | 25 ± 12a | 22 ± 20a | 14 ± 8 | 15 ± 8 | <0.001 |
| Glucose/insulin (ratio) | 4.4 ± 2.4a | 5.6 ± 3.2a | 7.3 ± 2.8 | 6.6 ± 2.9 | <0.001 |
| HOMA IR | 5.6 ± 3.2a | 4.8 ± 4.8e | 3.0 ± 1.8 | 3.2 ± 1.7 | <0.001 |
HA, HA phenotype; UA, unaffected sisters. P value, ANOVA adjusted for age and BMI with least significant difference post hoc test.
To convert total T and uT to nanomoles per liter, multiply by 0.0345. To convert glucose to millimoles per liter, multiply by 0.05551. To convert insulin to picomoles per liter, multiply by 6.
a
P < 0.05 vs. unaffected sisters and control.
b
P < 0.05 vs. HA and unaffected sisters.
c
P < 0.05 vs. PCOS and unaffected sisters.
d
P < 0.05 vs. PCOS, HA, and control.
e
P < 0.05 vs. control.