Table 4. Hippocampal gene expression following 40 days of dietary and VWR treatment.

Gene	Group				Statistics (p values)
	Con-SED	EGCG/β-ala-SED	Con-VWR	EGCG/β-ala-VWR	Diet	VWR	Diet × VWR
Neurotrophins
Bdnf	1.01 ± 0.04	0.88 ± 0.03	1.11 ± 0.06	1.16 ± 0.09	0.89	0.01	0.45
Ngf	1.03 ± 0.08	0.98 ± 0.08	1.05 ± 0.04	0.96 ± 0.05	0.29	0.94	0.73
Igf1	1.03 ± 0.07	1.12 ± 0.08	1.13 ± 0.07	1.12 ± 0.08	0.62	0.52	0.54
Vegfa	1.00 ± 0.04	0.92 ± 0.09	1.00 ± 0.09	0.86 ± 0.07	0.14	0.74	0.19
Tgfb1	1.05 ± 0.07	1.00 ± 0.10	1.12 ± 0.07	1.01 ± 0.07	0.33	0.62	0.64
Pro-inflammatory
Tnf	1.00 ± 0.17	0.83 ± 0.14	0.99 ± 0.10	0.71 ± 0.10	0.08	0.59	0.63
Il1b	1.00 ± 0.11	0.82 ± 0.11	0.68 ± 0.08	0.65 ± 0.06	0.54	0.01	0.24
Il6	1.10 ± 0.17	1.09 ± 0.14	1.33 ± 0.17	1.23 ± 0.20	0.78	0.30	0.79
Itgam (Cd11b)	1.02 ± 0.06	0.96 ± 0.07	0.82 ± 0.04	0.79 ± 0.04	0.35	0.001	0.81
Chemokines
Ccl2	1.00 ± 0.14	0.90 ± 0.14	0.96 ± 0.14	0.93 ± 0.20	0.68	0.98	0.82
Cx3cl1	0.99 ± 0.03	0.88 ± 0.06	1.01 ± 0.04	0.94 ± 0.04	0.05	0.35	0.66
Cxcl12	1.00 ± 0.04	1.00 ± 0.11	1.03 ± 0.06	0.86 ± 0.05	0.18	0.42	0.23

Values are reported relative to Con-SED using ∆∆CT method and GAPDH as the control gene. n=8-12/treatment.