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. 2015 May 12;10(5):e0122335. doi: 10.1371/journal.pone.0122335

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© 2015 Chan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 5 — Immunostaining with the neuronal-specific marker NeuN in the striatum in 5-year-old control (a), rHD7 (b), and rHD1 (c) monkeys (scale bar = 1mm). The close-up view at the right side shows a closer view of the caudate nucleus and putamen (scale bar = 100μm). The number of NeuN-positive neurons in the caudate nucleus (a’, b’, c’) and putamen (a”, b”, c”) of the HD monkeys is dramatically reduced compared with the control animal (scale bar = 10 μm). By counting from the Nissl staining, the number of neurons in the caudate nucleus and putamen is reduced in both HD monkeys when compared to control monkeys (d, e, respectively).