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Panel A: OTP (SQ) dose-dependently protects mice from a lethal dose of 6.3 Gy radiation when administered −30 min relative to the time of TBI (n =12 for all groups, *P < 0.01 vs. vehicle). Panel B: A single 1 mg/kg dose of OTP (SQ) is as effective as two (1 mg/kg at + 24 h and +48 h postirradiation) or three doses (1 mg/kg at +24 h, +48 h and +72 h postirradiation) at protecting mice from a lethal dose of radiation (6.3 Gy) (n = 18 per group,*P < 0.03 vs. vehicle).
