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OTP protects mice from 6.3 Gy of TBI when administered −24 h to +26 h relative to the time of TBI. (n = 12–24 per group). Panel A shows the radioprotective effects of OTP (1 mg/kg, SQ, *P < 0.02 vs. vehicle) administered at −12 h or −24 h prior to irradiation. Panel B shows the radiomitigative effects of OTP (1 mg/kg, SQ, *P < 0.03 or **P < 0.002 vs. vehicle) administered at +12 h or + 26 h postirradiation.
