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. Author manuscript; available in PMC: 2015 May 12.
Published in final edited form as: Inflamm Bowel Dis. 2014 Dec;20(12):2364–2378. doi: 10.1097/MIB.0000000000000142

FIGURE 2.

FIGURE 2

MCs in the colonic mucosa of a patient with IBD. A patient with active UC underwent colonoscopy to determine the extent and severity of the colitis. H&E histochemistry, performed on sections of a biopsy from an inflamed segment, revealed acute and chronic inflammatory changes in the mucosa at low ×20 (A) and higher ×40 power (B). To visualize the Kit+ MCs in the biopsy, replicate sections were stained with an antibody that recognizes this tyrosine kinase receptor. Kit+ MCs were interspersed throughout the lamina propria (black arrows) at low ×20 (C) and higher ×40 power (D). There were no aggregates or sheets of MCs that would be consistent with systemic mastocytosis. Images courtesy of Jason Hornick, MD, Department of Pathology, Brigham and Women’s Hospital.