Table 2. Novel differentially expressed genes in response to S. japonicum soluble egg antigen (SEA).
| FC SEA / control (hours) | |||||||
|---|---|---|---|---|---|---|---|
| Symbol | 4 | p-Value | 24 | p-Value | 48 | p-Value | Definition |
| angpt2 | -3.1 | 1.20E-05 | 1 | 9.96E-01 | 1.1 | 1.00E+00 | angiopoietin 2 |
| aqp1 | 1 | 4.78E-01 | -3 | 1.40E-04 | -2.3 | 2.80E-03 | aquaporin 1 |
| ccl2 | 1.8 | 9.19E-03 | 1.7 | 1.47E-02 | 1.3 | 1.00E+00 | chemokine (C-C motif) ligand 2 |
| ccl7 | 1.1 | 6.38E-01 | 1.8 | 3.38E-02 | 1.7 | 1.00E+00 | chemokine (C-C motif) ligand 7 |
| ccrl2 | 1.4 | 1.44E-02 | 1.5 | 1.14E-02 | 1.2 | 1.00E+00 | chemokine (C-C motif) receptor-like 2 |
| cd14 | 1.3 | 1.07E-01 | 1.2 | 1.70E-01 | 1.9 | 6.04E-04 | CD14 antigen |
| col1a1 | -1.1 | 2.65E-01 | -1.1 | 2.61E-01 | 1.4 | 6.64E-03 | procollagen, type I, alpha 1 |
| col5a1 | 1.1 | 3.80E-01 | 1 | 8.40E-01 | 1.7 | 3.41E-01 | procollagen, type V, alpha 1 |
| cxcl1 | 1.1 | 2.60E-01 | 1 | 7.51E-01 | 2.2 | 2.30E-05 | chemokine (C-X-C motif) ligand 1 |
| cxcl16 | 1.6 | 2.10E-03 | 1.5 | 3.18E-04 | 1.3 | 9.30E-01 | chemokine (C-X-C motif) ligand 16 |
| fstl1 | 1 | 8.81E-01 | -1.1 | 2.61E-01 | 1.7 | 1.26E-01 | follistatin-like 1 |
| ifit3 | -1.2 | 4.36E-01 | 2.3 | 3.09E-02 | 1 | 1.00E+00 | interferon-induced protein with tetratricopeptide repeats 3. |
| iigp2 | -1.5 | 1.91E-03 | 1.8 | 1.74E-06 | 1.1 | 1.00E+00 | interferon inducible GTPase 2 |
| il10 | 1.9 | 6.79E-08 | 1.2 | 4.53E-03 | 1.2 | 1.00E+00 | interleukin 10 |
| il11 | -1.3 | 8.55E-02 | -1.2 | 3.57E-01 | 2.4 | 1.06E-04 | interleukin 11 |
| il4i1 | 1.8 | 1.09E-06 | 1.2 | 3.72E-03 | 1.3 | 9.75E-01 | interleukin 4 induced 1 |
| il6 | -1.1 | 3.87E-01 | 1 | 9.50E-01 | 2.3 | 4.17E-03 | interleukin 6 |
| irak3 | 1.3 | 8.93E-03 | 1.8 | 9.76E-05 | 2.6 | 3.34E-05 | interleukin-1 receptor-associated kinase 3 |
| loc100044702 | -1.2 | 2.05E-01 | 1.1 | 5.54E-01 | 2.7 | 4.19E-03 | similar to LPS-induced CXC chemokine. |
| ly6a | -1.4 | 3.47E-03 | 2.1 | 7.11E-04 | 1 | 1.00E+00 | lymphocyte antigen 6 complex, locus A |
| mmp10 | 1 | 7.21E-01 | 1.3 | 1.06E-01 | 1.8 | 1.00E+00 | matrix metallopeptidase 10 |
| mmp3 | 1 | 9.65E-01 | -1.1 | 7.73E-01 | 1.7 | 7.94E-02 | matrix metallopeptidase 3 |
| mmp9 | 1 | 6.94E-01 | 1.4 | 1.14E-01 | 2.1 | 3.44E-03 | matrix metallopeptidase 9 |
| pglyrp1 | -1.1 | 3.78E-01 | 1.2 | 1.24E-02 | 1.7 | 3.12E-03 | Peptidoglycan recognition protein |
| serpinb2 | 1.1 | 1.11E-01 | 1.1 | 5.22E-01 | 2.5 | 4.89E-05 | serine (or cysteine) peptidase inhibitor, clade B, member 2. |
| sod2 | 1 | 9.87E-01 | 1.2 | 3.69E-02 | 1.8 | 9.06E-03 | Superoxide dismutase 2, mitochondrial |
| timp1 | -1.1 | 7.66E-01 | -1.1 | 5.10E-01 | 2.1 | 2.76E-03 | tissue inhibitor of metalloproteinase 1 |
| tnc | 1 | 6.29E-01 | -1.2 | 1.28E-01 | 2.3 | 9.88E-02 | tenascin C |
| tnf | 1.9 | 2.27E-04 | 1.3 | 3.90E-03 | 1.2 | 1.00E+00 | tumor necrosis facto |
| tlr4 | -1.1 | 1.94E-01 | 1 | 9.19E-01 | 1 | 1.00E+00 | toll-like receptor 4 |
Gene expression fold changes (FC) with associated p-value, relative to control tissue in ex vivo native mouse liver model over 48 hours after the addition of SEA. Genes with known roles in immune responses or tissue remodeling are shown.