Table 3. Top 20 pathways identified by Ingenuity Pathway Analysis.

Ingenuity Canonical Pathways	P-value	Genes
Granulocyte Adhesion and Diapedesis	4.37E-09	CXCL3, IL1A, CCL4, FPR2, CCL3L1/CCL3L3, MMP13, IL1B, FPR1
Atherosclerosis Signaling	9.55E-09	IL1A, CD40, CSF1, LPL, MMP13, IL1B, S100A8
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis	2.04E-08	TLR2, IL1A, CSF1, MMP13, OSM, IL1B, IRAK3, TCF7L2, TRAF1
Communication between Innate and Adaptive Immune Cells	5.13E-08	TLR2, IL1A, CCL4, CD40, CCL3L1/CCL3L3, IL1B
Hepatic Fibrosis / Hepatic Stellate Cell Activation	6.46E-07	CXCL3, IL1A, CD40, CSF1, MMP13, IL1B
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis	1.35E-06	TLR2, IL1A, CD40, CSF1, IL1B
NF-ΰB Signaling	2.29E-06	TLR2, IL1A, TNIP1, CD40, IL1B, IRAK3
Agranulocyte Adhesion and Diapedesis	3.39E-06	CXCL3, IL1A, CCL4, CCL3L1/CCL3L3, MMP13, IL1B
LXR/RXR Activation	7.41E-06	IL1A, LPL, IL1B, S100A8, ARG2
Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F	1.82E-05	IL1A, CCL4, IL1B
TREM1 Signaling	2.40E-05	TLR2, CXCL3, CD40, IL1B
Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis	1.29E-04	IL1A, CSF1, MMP13, IL1B, TCF7L2
Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza	1.32E-04	IL1A, CCL4, IL1B
Role of IL-17F in Allergic Inflammatory Airway Diseases	1.41E-04	CCL4, MMP13, IL1B
Hepatic Cholestasis	2.63E-04	IL1A, SLCO3A1, IL1B, IRAK3
Toll-like Receptor Signaling	2.69E-04	TLR2, IRAK3, TRAF1
Role of IL-17A in Psoriasis	3.80E-04	CXCL3, S100A8
IL-10 Signaling	4.79E-04	IL1A, IL1B, ARG2
Acute Phase Response Signaling	5.50E-04	IL1A, Saa3, OSM, IL1B
Dendritic Cell Maturation	6.76E-04	TLR2, IL1A, CD40, IL1B

From the 48 differentially expressed genes in response to S. japonicum soluble egg antigen in the ex vivo native mouse liver model over 48 hours.