Table 2. Summary of multi-domain phenotypic changes across age in R6/1 mice.
Age (weeks) | Phenotypes in R6/1 mice |
---|---|
9–12 | Delta power decreaseSleep fragmentationSpatial working memory impairment |
13–16 | Breakdown of circadian rhythm |
17–20 | Motor coordination and grip strength deficits, ClaspingDeficits in olfactory discriminationBody weight loss |
21–24 | Deficits in odor detectionDeficits in social behavior and ultrasonic vocalization |