Table 2. Summary of multi-domain phenotypic changes across age in R6/1 mice.

Age (weeks)	Phenotypes in R6/1 mice
9–12	Delta power decreaseSleep fragmentationSpatial working memory impairment
13–16	Breakdown of circadian rhythm
17–20	Motor coordination and grip strength deficits, ClaspingDeficits in olfactory discriminationBody weight loss
21–24	Deficits in odor detectionDeficits in social behavior and ultrasonic vocalization