Table 1.

Primary screening of the protective effects of 7-methoxy-N-(substituted phenyl)benzofuran-2-carboxamide derivatives against NMDA-induced excitotoxicity in primary cortical neuronal culture

Compound	Substituents			Cell viability (% control)1
	R1	R2	R3	NMDA2	NMDA + derivatives
					10 μM	100 μM
1a	H	H	H	65.86 ± 4.68	73.34 ± 8.23	89.88 ± 9.41
1b	OCH3	H	H		64.69 ± 6.80	67.99 ± 0.23
1c	H	OCH3	H		73.98 ± 10.06	83.14 ± 12.45
1d	H	H	OCH3		43.70 ± 13.91	59.81 ± 1.27
1e	CH3	H	H		44.21 ± 18.52	62.23 ± 4.71
1f	H	CH3	H		83.57 ± 7.88	89.66 ± 6.27
1g	H	H	CH3		44.60 ± 23.62	63.78 ± 0.23
1h	OH	H	H		48.93 ± 28.93	63.44 ± 12.04
1i	H	OH	H		62.13 ± 12.48	80.79 ± 3.22
1j	H	H	OH		55.13 ± 7.69	90.43 ± 2.19
1k	Cl	H	H		68.95 ± 0.40	61.36 ± 3.87
1l	H	Cl	H		62.30 ± 10.51	87.04 ± 17.18
1m	H	H	Cl		71.16 ± 2.28	71.58 ± 2.07
1n	H	NO2	H		71.56 ± 4.55	57.40 ± 4.83
1o	H	H	NO2		75.06 ± 3.18	70.65 ± 9.20
1p	CF3	H	H		63.45 ± 7.41	76.98 ± 8.88
1q	H	CF3	H		66.76 ± 8.41	80.02 ± 5.63
1r	H	H	CF3		62.38 ± 7.59	74.91 ± 8.96

The viability of the cells treated with NMDA or NMDA + derivatives is expressed as % of control.

¹The values represent the Mean ± SEM of three individual assays.

²The value represents the Mean ± SEM of averages of all NMDA data collected from assays of the individual derivatives.