(A) Average effect on general motility in response to SCS. Each color line represents one recorded animal over all trials. (B-D), Average recovery of locomotion: bout distance, bout frequency and duration, respectively (colors represent the four different subjects and asterisks denote significant group differences). (E), Reduction in bradykinesia reflected by the preferential recovery of faster movement components in locomotion. (F), Average improvements in PD-score in all testing sessions divided by symptom category (mean and SEM shown). (G), Example of functional motor improvement from a state of severe Parkinsonism enabling an animal to retrieve food rewards using skilled reaching and grasping movements.