Table 2. Complete list of significant differentially expressed miRNA (p-value < 0.05) in lung cancer patients as compared with controls in the IARC case-control study (Moscow, Russia, 2006–2012)—global miRNA expression profiling using TaqMan Human MicroRNA Array A + B Card Set (v3.0).
| miRNA | p-value a | adj. p-value b | FC | TLDA card |
|---|---|---|---|---|
| miR-340#-002259 | 5.99E-06 | 0.0006 | 2.92 | B |
| miR-218-000521 | 6.68E-06 | 0.0010 | 0.29 | A |
| miR-450b-5p-002207 | 1.04E-05 | 0.0010 | 0.31 | A |
| miR-566-001533 | 0.0003 | 0.0144 | 0.30 | B |
| miR-661-001606 | 0.0005 | 0.0160 | 0.36 | B |
| miR-200c-002300 | 0.0004 | 0.0212 | 2.65 | A |
| miR-323-3p-002227 | 0.0005 | 0.0212 | 0.55 | A |
| miR-642-001592 | 0.0007 | 0.0212 | 0.43 | A |
| miR-28-000411 | 0.0007 | 0.0212 | 1.91 | A |
| miR-1290-002863 | 0.0011 | 0.0264 | 0.54 | B |
| miR-590-3P-002677 | 0.0012 | 0.0264 | 2.29 | B |
| miR-485-3p-001277 | 0.0012 | 0.0331 | 0.56 | A |
| miR-22#-002301 | 0.0021 | 0.0364 | 2.18 | B |
| miR-191#-002678 | 0.0027 | 0.0402 | 2.88 | B |
| miR-26b#-002444 | 0.0039 | 0.0442 | 3.08 | B |
| miR-34b-002102 | 0.0042 | 0.0442 | 0.39 | B |
| miR-425#-002302 | 0.0043 | 0.0442 | 2.24 | B |
| miR-766-001986 | 0.0046 | 0.0442 | 1.65 | B |
| miR-203-000507 | 0.0019 | 0.0445 | 0.37 | A |
| miR-193a-5p-002281 | 0.0024 | 0.0474 | 0.49 | A |
| miR-25-000403 | 0.0025 | 0.0474 | 0.62 | A |
| miR-517b-001152 | 0.0033 | 0.0515 | 0.28 | A |
| miR-487a-001279 | 0.0033 | 0.0515 | 0.40 | A |
| miR-1275-002840 | 0.0065 | 0.0571 | 0.42 | B |
| miR-122-002245 | 0.0041 | 0.0591 | 0.53 | A |
| miR-378-000567 | 0.0078 | 0.0638 | 0.43 | B |
| miR-146a-000468 | 0.0059 | 0.0775 | 1.78 | A |
| miR-483-5p-002338 | 0.0065 | 0.0775 | 0.52 | A |
| miR-484-001821 | 0.0066 | 0.0775 | 1.90 | A |
| miR-93#-002139 | 0.0113 | 0.0857 | 1.73 | B |
| miR-652-002352 | 0.0103 | 0.1064 | 1.70 | A |
| miR-708-002341 | 0.0105 | 0.1064 | 0.38 | A |
| miR-339-3p-002184 | 0.0107 | 0.1064 | 1.64 | A |
| miR-200a-000502 | 0.0118 | 0.1086 | 0.46 | A |
| miR-182-002334 | 0.0121 | 0.1086 | 0.56 | A |
| miR-1243-002854 | 0.0176 | 0.1241 | 0.37 | B |
| let-7f-000382 | 0.0150 | 0.1278 | 3.13 | A |
| miR-151-3p-002254 | 0.0215 | 0.1390 | 1.63 | B |
| miR-1271-002779 | 0.0235 | 0.1390 | 1.75 | B |
| miR-454#-001996 | 0.0236 | 0.1390 | 1.84 | B |
| let-7b-002619 | 0.0188 | 0.1488 | 1.33 | A |
| miR-140-001187 | 0.0190 | 0.1488 | 1.52 | A |
| miR-26a-000405 | 0.0217 | 0.1632 | 1.36 | A |
| miR-155-002623 | 0.0226 | 0.1633 | 1.54 | A |
| miR-645-001597 | 0.0305 | 0.1702 | 0.56 | B |
| miR-191-002299 | 0.0249 | 0.1728 | 1.35 | A |
| miR-221-000524 | 0.0261 | 0.1728 | 1.46 | A |
| miR-18a-002422 | 0.0267 | 0.1728 | 1.75 | A |
| miR-1285-002822 | 0.0332 | 0.1757 | 0.34 | B |
| miR-30d#-002305 | 0.0385 | 0.1802 | 1.90 | B |
| miR-130b#-002114 | 0.0407 | 0.1802 | 2.14 | B |
| miR-7#-001338 | 0.0418 | 0.1802 | 1.37 | B |
| miR-30a-3p-000416 | 0.0425 | 0.1802 | 1.57 | B |
| miR-335#-002185 | 0.0425 | 0.1802 | 1.64 | B |
| miR-1233-002768 | 0.0452 | 0.1842 | 0.46 | B |
| miR-495-001663 | 0.0315 | 0.1953 | 0.44 | A |
| miR-758-001990 | 0.0322 | 0.1953 | 0.56 | A |
| miR-223-002295 | 0.0425 | 0.2497 | 1.51 | A |
| miR-411-001610 | 0.0479 | 0.2676 | 0.60 | A |
| miR-19b-000396 | 0.0493 | 0.2676 | 1.54 | A |
| miR-26b-000407 | 0.0498 | 0.2676 | 1.48 | A |
a Limma analysis non-adjusted p-value.
b p-value corrected for multiple testing (Benjamini-Holm method).
FC: fold change (> 1 increased; < 1 decreased expression in lung cancer patients vs. non-cancer controls).